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Case Reports
. 2010 Nov;22(4):472-7.
doi: 10.5021/ad.2010.22.4.472. Epub 2010 Nov 5.

A case of primary cutaneous mucinous carcinoma with neuroendocrine differentiation

June-Bum Kim  1 , Ji-Hyun Choi, Ji-Hye Kim, Hyang-Joon Park, Jae-Seung Lee, Ok-Ja Joh, Kye Yong Song
Affiliations
Case Reports

A case of primary cutaneous mucinous carcinoma with neuroendocrine differentiation

June-Bum Kim et al. Ann Dermatol. 2010 Nov.

Abstract

Primary cutaneous mucinous carcinoma is a rare malignant tumor that originates from the deepest portion of the eccrine sweat duct. Common sites of involvement are the face and scalp. Biopsy shows dermal epithelial cell islands embedded in mucin pools separated by fibrous septae. It is difficult to differentiate this tumor histologically from metastatic adenocarcinoma. Recurrence after excision is common but metastases are rare. We report a primary cutaneous mucinous carcinoma with neuroendocrine differentiation on the right cheek of a 63-year-old man.

Keywords: Cutaneous mucinous carcinoma; Eccrine sweat duct; Metastatic adenocarcinoma; Neuroendocrine differentiation.

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Figures

Fig. 1
Fig. 1
(A) 1×1 cm sized erythematous dome-shaped nodule on right malar area. (B) Closer view.
Fig. 2
Fig. 2
(A) Well-defined lobulated tumor nodule occupying the lower dermis and subcutaneous tissue (H&E stain, ×40). (B) Islands of uniform-appearing epithelial cells within abundant pools of mucin, separated by thin fibrovascular septae (H&E stain, ×400).
Fig. 3
Fig. 3
Tumor cells floating in the mucin pool (A: Alcian blue, ×400; B: PAS, ×400).
Fig. 4
Fig. 4
Results of immunohistochemical staining showed a positive reaction of synaptophysin (A), cytokeratin 7 (B), estrogen receptor (C), and progesterone receptor (D), and a negative reaction of cytokeratin 20 (E) (×400).
See this image and copyright information in PMC

References

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