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Review
. 2010 Dec;83(4):209-15.

Toward novel vaccines against tuberculosis: current hopes and obstacles

Christoph A Thaiss  1 , Stefan H E Kaufmann
Affiliations
Review

Toward novel vaccines against tuberculosis: current hopes and obstacles

Christoph A Thaiss et al. Yale J Biol Med. 2010 Dec.

Abstract

Approximately 2 million people die of tuberculosis (TB) each year. The current vaccine, Bacille Calmette-Guérin (BCG), albeit widely employed, does not protect against adult pulmonary disease, and new vaccines are urgently needed to reduce the incidence of TB worldwide. New insights into the cellular and molecular mechanisms that underlie the interactions between Mycobacterium tuberculosis and its host have been exploited to develop novel vaccine candidates that recently have entered clinical trials. This review provides a brief overview of different approaches toward a new vaccination strategy and summarizes major challenges for the next decade.

Keywords: BCG; global open access; tuberculosis; vaccines.

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Conflict of interest statement

Conflict of interest: S.H.E. Kaufmann is co-inventor of the rBCGΔUreC:Hly vaccine candidate.

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