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. 2010 Nov;149(6):677-81.
doi: 10.1007/s10517-010-1022-0.

Monitoring of motor disorders in 7-day-old rats with severe hypoxic-ischemic injury of the brain

A V Karasev  1 , S V Lebedev, T V Garats, A M Sharibzhanova, A V Makarov, N N Volodin, V P Chekhonin
Affiliations

Monitoring of motor disorders in 7-day-old rats with severe hypoxic-ischemic injury of the brain

A V Karasev et al. Bull Exp Biol Med. 2010 Nov.

Abstract

Seven-day old rats were subjected to unilateral ligation of the common carotid artery followed by 2-h exposure to a gas mixture consisting of 8% oxygen and 92% nitrogen. Locomotor function of rats was monitored weekly. Functional deficit in these animals persisted for at least 3 months. The exercise tests of rotarod, hanging, and narrowing track were most informative. Our results can be used in preclinical studies of new drugs for the therapy of perinatal brain injury.

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