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Controlled Clinical Trial
. 2010 Dec 19;12(5):e48.
doi: 10.2196/jmir.1370.

Multimodal e-mental health treatment for depression: a feasibility trial

David C Mohr  1 , Jennifer Duffecy, Ling Jin, Evette J Ludman, Adam Lewis, Mark Begale, Martin McCarthy Jr
Affiliations
Controlled Clinical Trial

Multimodal e-mental health treatment for depression: a feasibility trial

David C Mohr et al. J Med Internet Res. .

Abstract

Background: Internet interventions for depression have shown less than optimal adherence. This study describes the feasibility trial of a multimodal e-mental health intervention designed to enhance adherence and outcomes for depression. The intervention required frequent brief log-ins for self-monitoring and feedback as well as email and brief telephone support guided by a theory-driven manualized protocol.

Objective: The objective of this feasibility trial was to examine if our Internet intervention plus manualized telephone support program would result in increased adherence rates and improvement in depression outcomes.

Methods: This was a single arm feasibility trial of a 7-week intervention.

Results: Of the 21 patients enrolled, 2 (9.5%) dropped out of treatment. Patients logged in 23.2 ± 12.2 times over the 7 weeks. Significant reductions in depression were found on all measures, including the Patient Health Questionnaire depression scale (PHQ-8) (Cohen's d = 1.96, P < .001), the Hamilton Rating Scale for Depression (d = 1.34, P < .001), and diagnosis of major depressive episode (P < .001).

Conclusions: The attrition rate was far lower than seen either in Internet studies or trials of face-to-face interventions, and depression outcomes were substantial. These findings support the feasibility of providing a multimodal e-mental health treatment to patients with depression. Although it is premature to make any firm conclusions based on these data, they do support the initiation of a randomized controlled trial examining the independent and joint effects of Internet and telephone administered treatments for depression.

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Conflict of interest statement

David C Mohr, PhD, and Martin McCarthy Jr, PhD, hold copyrights to an earlier version of moodManager.

Figures

Figure 1
Figure 1
Flow of patients through recruitment, screen, and intervention
See this image and copyright information in PMC

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