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Comment
. 2011 Jan;12(1):14-6.
doi: 10.1038/ni0111-14.

Cooperative regulatory events and Foxp3 expression

Masahide Tone, Mark I Greene
Comment

Cooperative regulatory events and Foxp3 expression

Masahide Tone et al. Nat Immunol. 2011 Jan.

Abstract

The molecular mechanisms that control Treg and TH17 development and the precise role of transforming growth factor-β in this process are complex and imperfectly understood. New findings indicate that the helix-loop-helix proteins E2A and Id3 are also critically involved in some of these processes.

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Figures

Figure 1
Figure 1
Transcriptional regulation of Foxp3. (a) Structure of mouse Foxp3. Boxes indicate exons (numbers above). (b) Location of the Foxp3 promoter, enhancers (1 and 2) and CNS3 regions, as well as exons −2a, −2b, −1 and 1. Binding regions for regulators of Foxp3 transcription are above (negative regulators) and below (positive regulators). This model is based on many publications.
See this image and copyright information in PMC

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References

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