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. 2011 Feb;7(2):75-7.
doi: 10.1038/nchembio.496. Epub 2010 Dec 19.

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

Abdul Hakkim  1 , Tobias A Fuchs, Nancy E Martinez, Simone Hess, Heino Prinz, Arturo Zychlinsky, Herbert Waldmann
Affiliations

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

Abdul Hakkim et al. Nat Chem Biol. 2011 Feb.

Abstract

The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.

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