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Review
. 1990:168 Suppl:552-64.
doi: 10.1007/BF02718178.

The protease-antiprotease balance within the human lung: implications for the pathogenesis of emphysema

J E Gadek  1 , E R Pacht
Affiliations
Review

The protease-antiprotease balance within the human lung: implications for the pathogenesis of emphysema

J E Gadek et al. Lung. 1990.

Abstract

Critical elements of the mechanisms of emphysema remain to be clarified. However, taken together, the existing evidence supports the concept that alveolar matrix destruction ensues as the regulatory interplay between oxidant and protease expression is subverted. The final common pathway of matrix destruction links the inherited and acquired forms of emphysema through the ultimate expression of unimpeded neutrophil elastase.

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