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. 2010 Dec 16;7 Suppl 1(Suppl 1):S4.
doi: 10.1186/1742-4933-7-S1-S4.

Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia

Federico Licastro  1 , Elisa Porcellini, Paola Forti, Massimo Buscema, Ilaria Carbone, Giovanni Ravaglia, Enzo Grossi
Affiliations

Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia

Federico Licastro et al. Immun Ageing. .

Abstract

Background: The population longitudinal study named "The Conselice Study" has been the focus of the present investigation. 65 years old or older participants of this population study on brain aging were followed up for 5 years: 937 subjects completed the follow-up. Relationships of 46 genetic, phenotypic, clinical and nutritional factors on incident cognitive decline and incident dementia cases were investigated.

Results: A new statistical approach, called the Auto Contractive Map (AutoCM) was applied to find relationship between variables and a possible hierarchy in the relevance of each variable with incident dementia. This method, based on an artificial adaptive system, was able to define the association strength of each variable with all the others. Moreover, few variables resulted to be aggregation points in the variable connectivity map related to cognitive decline and dementia. Gene variants and cognate phenotypic variables showed differential degrees of relevance to brain aging and dementia. A risk map for age associated cognitive decline and dementia has been constructed and will be presented and discussed.

Conclusion: This map of variables may be use to identify subjects with increased risk of developing cognitive decline end/or dementia and provide pivotal information for early intervention protocols for prevention of dementia.

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Figures

Figure 1
Figure 1
Connectivity map of 42 epidemiological, genetic and clinical variables showing different output such as prevalent AD, prevalent VD, prevalent CIND and control cases
See this image and copyright information in PMC

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