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. 2010 Nov 16;2(11):379-80.
doi: 10.4253/wjge.v2.i11.379.

Cytomegalovirus gastritis

Akira Hokama  1 , Kiyohito Taira, Yu-Ichi Yamamoto, Nagisa Kinjo, Fukunori Kinjo, Kenzo Takahashi, Jiro Fujita
Affiliations

Cytomegalovirus gastritis

Akira Hokama et al. World J Gastrointest Endosc. .

Abstract

Cytomegalovirus (CMV) has been increasingly recognized as an important common pathogen in an immunocompromised state. The colon and stomach are the most common sites of its gastrointestinal infection. Symptoms of CMV gastritis are usually nonspecific and include epigastric pain, fever, nausea and bleeding. Endoscopic features are quite variable and include macroscopically normal mucosa, diffuse erythema, nodules, pseudotumors, erosions and ulcers. The bioptic detection of intranuclear inclusions is the hallmark of CMV infection. Most gastrointestinal CMV infection responds well to ganciclovir. We present endoscopic and histopathological features of CMV gastritis in a 71 year old woman receiving long-term prednisolone for pemphigus vulgaris.

Keywords: Cytomegalovirus; Endoscopy; Gastritis; Pemphigus vulgaris.

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Figures

Figure 1
Figure 1
Endoscopic and histopathological pictures of cytomegalovirus gastritis. A: Note numerous patchy erythemas in the gastric body; B: Closer observation showing the slightly depressed erythema; C: Histopathological examination of the erythema showing large epithelial cells with characteristic “owl’s eye” eosinophilic intranuclear inclusion body surrounded by a clear halo (H&E, × 200); D: Note positive immunostaining for cytomegalovirus antigens × 200).
See this image and copyright information in PMC

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