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Review
. 2012 Jun;42(3):269-78.
doi: 10.1007/s12016-010-8218-y.

Cutting edge issues in autoimmune gastritis

Ban-Hock Toh  1 , James Chan, Tin Kyaw, Frank Alderuccio
Affiliations
Review

Cutting edge issues in autoimmune gastritis

Ban-Hock Toh et al. Clin Rev Allergy Immunol. 2012 Jun.

Abstract

Autoimmune gastritis is the outcome of a pathological CD4 T cell-mediated autoimmune response directed against the gastric H/K-ATPase. Silent initially, the gastric lesion becomes manifest in humans by the development of megaloblastic pernicious anemia arising from vitamin B12 deficiency. Cutting edge issues in this disease relate to its epidemiology, immunogenetics, a role for Helicobacter pylori as an infective trigger through molecular mimicry, its immunopathogenesis, associated organ-specific autoimmune diseases, laboratory diagnosis, and approaches to curative therapy.

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