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. 1990 Jul 15;269(2):315-20.
doi: 10.1042/bj2690315.

The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide

M H Schaffer  1 , B E Noyes, C A Slaughter, G C Thorne, S J Gaskell
Affiliations

The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide

M H Schaffer et al. Biochem J. .

Abstract

A member of the RPCH/AKH (red-pigment-concentrating hormone/adipokinetic hormone) family of arthropod neuropeptides was identified in the fruitfly Drosophila melanogaster, and its structure was determined by automated Edman degradation and m.s. using fast-atom-bombardment ionization and a tandem hybrid instrument capable of high sensitivity. The sequence of this peptide, which we call 'DAKH', is pGlu-Leu-Thr-Phe-Ser-Pro-Asp-Trp-NH2 (where pGlu is pyroglutamic acid and Trp-NH2 is tryptophan carboxyamide). H.p.l.c. analyses of extracts of the three body segments revealed that more than 80% of the peptide is contained in the thorax. Although DAKH is typical of family members in its general structure and distribution in the animal, it is unique in containing a residue which is charged under physiological conditions. The evolutionary significance of this change is considered.

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