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. 2011;30(2):153-63.
doi: 10.3109/10641950903115012. Epub 2010 Dec 21.

Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia

Darcy B Carr  1 , Katherine M Newton, Kristina M Utzschneider, Mirjam V Faulenbach, Steven E Kahn, Thomas R Easterling, Susan R Heckbert
Affiliations
Free article

Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia

Darcy B Carr et al. Hypertens Pregnancy. 2011.
Free article

Abstract

Objective: We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia.

Methods: A retrospective cohort study was performed among 26,105 women.

Results: Preeclampsia was associated with the upper OGCT quartiles [114-132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09-1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21-1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09-1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15-1.83).

Conclusion: Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.

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