Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Sep 1;172(3):993-6.
doi: 10.1084/jem.172.3.993.

Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids

L X Liu  1 , C N Serhan, P F Weller
Affiliations

Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids

L X Liu et al. J Exp Med. .

Abstract

The nematode parasites that cause human lymphatic filariasis survive for long periods in their vascular habitats despite continual exposure to host cells. Since prostanoids formed from arachidonic acid can modulate interactions among platelets, leukocytes, and endothelial cells, we examined whether intravascular nematode parasites can elaborate prostanoids. Microfilariae of Brugia malayi utilize exogenous and endogenous arachidonic acid to generate and release two predominant prostanoids, prostacyclin and prostaglandin E2. Filarial metabolism of host fatty acids to form these vasodilatory, antiaggregatory, and immunomodulatory eicosanoids provides a means by which these helminthic parasites may influence host immune and other cellular responses.

PubMed Disclaimer

References

    1. Clin Immunol Immunopathol. 1983 Jul;28(1):67-76 - PubMed
    1. Prostaglandins Leukot Med. 1983 Jul;11(3):317-23 - PubMed
    1. Methods Enzymol. 1982;86:477-93 - PubMed
    1. J Immunol. 1989 Oct 1;143(7):2127-32 - PubMed
    1. Exp Parasitol. 1989 Aug;69(2):198-203 - PubMed

Publication types

MeSH terms