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Review
. 2011 Feb;27(1):11-20.
doi: 10.1016/j.hcl.2010.09.002.

Advances in the medical treatment of rheumatoid arthritis

J Michelle Kahlenberg  1 , David A Fox
Affiliations
Review

Advances in the medical treatment of rheumatoid arthritis

J Michelle Kahlenberg et al. Hand Clin. 2011 Feb.

Abstract

Over the past 2 decades, the treatment of rheumatoid arthritis (RA) has been revolutionized by advances in the understanding of its pathologic mechanisms and the development of drugs that target them. These newer medications have shown great promise at improving disease outcomes, but they come with notable side effects that can pose long-term treatment challenges and difficulties in the perioperative arena. In this article, the major manifestations of RA and the current medical options for management are discussed. Complications from treatment are then reviewed, and special consideration is given to perioperative medication recommendations.

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References

    1. Askling Ja, Bongartz Tb. Malignancy and biologic therapy in rheumatoid arthritis. Current Opinion in Rheumatology. 2008;20:334. - PubMed
    1. Bergholm R, Leirisalo-Repo M, Vehkavaara S, et al. Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis. Arterioscler Thromb Vasc Biol. 2002;22:1637. - PubMed
    1. Bongartz T, Halligan CS, Osmon DR, et al. Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. Arthritis Care & Research. 2008;59:1713. - PMC - PubMed
    1. Breedveld FC, Weisman MH, Kavanaugh AF, et al. The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis & Rheumatism. 2006;54:26. - PubMed
    1. Chan ESL, Cronstein B. Methotrexate--how does it really work? Nature Reviews Rheumatology. 2010;6:175. - PubMed

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