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. 1990 Sep;10(9):4932-4.
doi: 10.1128/mcb.10.9.4932-4934.1990.

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML

E C Park  1 , J W Szostak
Affiliations

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML

E C Park et al. Mol Cell Biol. 1990 Sep.

Abstract

The N-terminal serine and four conserved lysine residues near the N-terminus of yeast histone H4 are acetylated. We found that a mutation that changed the fourth lysine to alanine resulted in specific derepression of the silent mating type locus HML, while mutations that altered the N-terminal serine or the first three lysines had only minor phenotypic effects. Our results support an active role for histone H4 in the silencing of gene expression at this locus.

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References

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