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. 1990 Sep;10(9):4978-83.
doi: 10.1128/mcb.10.9.4978-4983.1990.

Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex

M C Birchenall-Roberts  1 , F W Ruscetti, J Kasper, H D Lee, R Friedman, A Geiser, M B Sporn, A B Roberts, S J Kim
Affiliations

Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex

M C Birchenall-Roberts et al. Mol Cell Biol. 1990 Sep.

Abstract

Growth factor-independent 32D-src and 32D-abl cell lines, established by infecting the interleukin-3-dependent myeloid precursor cell line (32D-123) with retroviruses containing the src or abl oncogene, were used to study transcriptional regulation of transforming growth factor beta 1 (TGF-beta 1) mRNA. Analysis of different TGF-beta 1 promoter constructs regulated by pp60v-src indicated that sequences responsive to high levels of src induction contain binding sites for AP-1. Both src and serum induced expression of the c-fos and c-jun genes in myeloid cells, resulting in transcriptional activation of the TGF-beta 1 gene. We found that serum treatment increased TGF-beta 1 mRNA levels in 32D-123 cells and that the v-Src protein could replace the serum requirement by stimulating binding to the AP-1 complex of the TGF-beta 1 promoter, thereby mediating the induction of TGF-beta 1 transcription.

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References

    1. Br J Cancer. 1988 Jun;57(6):594-600 - PubMed
    1. J Biol Chem. 1988 Jun 5;263(16):7741-6 - PubMed
    1. J Biol Chem. 1989 Jan 5;264(1):402-8 - PubMed
    1. Nature. 1989 Feb 16;337(6208):661-3 - PubMed
    1. J Biol Chem. 1989 Apr 25;264(12):7041-5 - PubMed

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