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. 1978 Sep 15;43(3):229-33.
doi: 10.1007/BF00691583.

Ultrastructural localization of rabies virus antigens in infected trigeminal ganglion of hamsters

T Yamamoto, S Ohtani

Ultrastructural localization of rabies virus antigens in infected trigeminal ganglion of hamsters

T Yamamoto et al. Acta Neuropathol. .

Abstract

The trigeminal ganglion of hamsters infected with CVS strain of rabies virus was investigated by electron microscopy with peroxidase-labeled antibody. Major localization of virus antigens were the following three types of structures; rabies virion, cytoplasmic inclusion, and ribosomal granules consisting of Nissl body. Rabies virions in neurons were mostly found within the cluster of such ribosome-rich regions suggesting a close relationship between the two in the synthesis of virus antigen. The cytoplasmic inclusion appeared to be derived from ribosomal or allied particles with virus-specific antigens. The significance of results obtained is briefly discussed.

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