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. 2011 Mar;64(3):229-32.
doi: 10.1038/ja.2010.165. Epub 2010 Dec 22.

Phenalinolactones A-D, terpenoglycoside antibiotics from Streptomyces sp. Tü 6071

Klaus Gebhardt  1 , Sven W Meyer, Jochen Schinko, Gerhard Bringmann, Axel Zeeck, Hans-Peter Fiedler
Affiliations

Phenalinolactones A-D, terpenoglycoside antibiotics from Streptomyces sp. Tü 6071

Klaus Gebhardt et al. J Antibiot (Tokyo). 2011 Mar.

Abstract

Four new terpenoglycoside antibiotics, phenalinolactones A-D were isolated from Streptomyces sp. Tü 6071. The structures were elucidated on the basis of detailed NMR and MS analyses. Phenalinolactones combine a diterpenoid tricycle, a 2,3,6-trideoxysugar, a pyrrole-carboxylic acid and an uncommonly oxidized unsaturated γ-lactone in a unique manner. Phenalinolactones show an inhibitory activity against gram-positive bacteria.

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