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. 2010 Dec;25(4):422-8.
doi: 10.3904/kjim.2010.25.4.422. Epub 2010 Nov 27.

Association of the superoxide dismutase (V16A) and catalase (C262T) genetic polymorphisms with the clinical outcome of patients with acute paraquat intoxication

Joong-Rock Hong  1 , Su-Jin Seok, Du-Shin Jeong, Sang-Gon Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Affiliations

Association of the superoxide dismutase (V16A) and catalase (C262T) genetic polymorphisms with the clinical outcome of patients with acute paraquat intoxication

Joong-Rock Hong et al. Korean J Intern Med. 2010 Dec.

Abstract

Background/aims: Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical outcome in patients with acute PQ intoxication.

Methods: We investigated whether there was a relationship between the genetic polymorphisms of SOD (V16A), catalase (C262T), and GPX1 (C593T) in 62 patients with acute PQ intoxication and the clinical outcomes of these patients.

Results: The frequency of the Mn-SOD V/V, V/A, and A/A genotypes were 56.3, 43.5, and 0% in survivors and 86.9, 13.1, and 0% in non-survivors (p > 0.05). The GPX1 C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of all subjects. The catalase C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of survivors, and in 82.6, 17.4, and 0% of non-survivors. Neither erythrocyte SOD activity nor catalase activity were significantly different between survivors and non-survivors.

Conclusions: No association was found between clinical outcome of acute PQ intoxication and the genetic polymorphism of GPX1 (C593T) or the genetic polymorphisms or enzyme activity of superoxide dismutase (V16A) or catalase (C262T).

Keywords: Catalase; Glutathione peroxidase GPX1; Paraquat; Polymorphism, genetic; Superoxide dismutase.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
(A) The upper and lower limit of paraquat level among survivors and non-survivors in 375 patients with acute paraquat intoxication (x: non-survivors, o: survivors). (B) These levels can be divided into a dead zone (above the upper line), gray zone (between the two lines; may die or may live), and a safe zone (below the lower line).
Figure 2
Figure 2
Comparison of superoxide dismutase (SOD) and catalase activity according to genotype. (A) There were no significant differences in SOD activity between the T/T and T/C polymorphism (p = 0.774). (B) There were no significant difference in catalase activity between the C/C and C/T polymorphism (p = 0.479).
See this image and copyright information in PMC

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