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Case Reports
. 1990 Aug;74(8):502-4.
doi: 10.1136/bjo.74.8.502.

Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis

C M Antle  1 , K F Damji, V A White, J Rootman
Affiliations
Case Reports

Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis

C M Antle et al. Br J Ophthalmol. 1990 Aug.

Abstract

A case of uveal malignant melanoma and contralateral optic nerve glioma is described in a 53-year-old Caucasian male with multiple uveal melanocytic hamartomas and neurofibromatosis. The eye was enucleated, and histologically the melanoma was found to consist of 70% epithelioid cells, with many bizarre, multinucleated forms. CT scan demonstrated a non-enhancing, fusiform enlargement of the contralateral optic nerve with enlargement of the optic canal and intracranial extension. This combination of tumours has not previously been reported in a patient with neurofibromatosis and serves to emphasise the common neuroectodermal origin of tumours in this autosomal dominant condition.

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References

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