Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec 28;16(48):6123-7.
doi: 10.3748/wjg.v16.i48.6123.

Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders

Andrea Pietrobattista  1 , Matteo Luciani, Juan G Abraldes, Manila Candusso, Simona Pancotti, Massimo Soldati, Lidia Monti, Giuliano Torre, Valerio Nobili
Affiliations

Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders

Andrea Pietrobattista et al. World J Gastroenterol. .

Abstract

Aim: to explore the prevalence of local and genetic thrombophilic disorders as risk factors for portal vein thrombosis (PVT) in our series, the largest ever published in pediatric literature.

Methods: we conducted a case-control study enrolling 31 children with PVT and 26 age-matched controls. All were screened for thrombophilia, including genetic disorders, protein C, protein S and homocysteine deficiencies. All coagulation parameters were studied at least 3 mo after the diagnosis of portal vein obstruction.

Results: in our study we showed that most pediatric patients with PVT have local prothrombotic risk factors, which are probably the most important factors leading to PVT. However, there is a clear association between the presence of prothrombotic disorders and PVT, suggesting that these increase the risk of thrombosis in patients with local factors such as perinatal umbilical vein catheterization or sepsis.

Conclusion: patients with PVT should be screened for inherited prothrombotic disorders regardless of a history of an obvious local risk factor.

PubMed Disclaimer

References

    1. Heller C, Schobess R, Kurnik K, Junker R, Günther G, Kreuz W, Nowak-Göttl U. Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study Group. Br J Haematol. 2000;111:534–539. - PubMed
    1. Uttenreuther-Fischer MM, Vetter B, Hellmann C, Otting U, Ziemer S, Hausdorf G, Gaedicke G, Kulozik AE. Paediatric thrombo-embolism: the influence of non-genetic factors and the role of activated protein C resistance and protein C deficiency. Eur J Pediatr. 1997;156:277–281. - PubMed
    1. Yamada RM, Antunes MM, Cardoso SR, Servidoni Mde F, Hessel G. [Portal vein thrombosis in children: clinical and laboratory study of 26 cases] Arq Gastroenterol. 1999;36:49–53. - PubMed
    1. Nowak-Göttl U, Junker R, Kreuz W, von Eckardstein A, Kosch A, Nohe N, Schobess R, Ehrenforth S. Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. Blood. 2001;97:858–862. - PubMed
    1. Kosch A, Junker R, Kurnik K, Schobess R, Günther G, Koch H, Nowak-Göttl U. Prothrombotic risk factors in children with spontaneous venous thrombosis and their asymptomatic parents: a family study. Thromb Res. 2000;99:531–537. - PubMed