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. 1978 Jul;39(7):546-56.
doi: 10.1080/0002889778507807.

Hapten-specific respiratory hypersensitivity in guinea pigs

M H Karol, H H Ioset, E J Riley, Y C Alarie

Hapten-specific respiratory hypersensitivity in guinea pigs

M H Karol et al. Am Ind Hyg Assoc J. 1978 Jul.

Abstract

Respiratory hypersensitivity to small chemical determinants (haptens) was produced in guinea pigs by repeatedly exposing the animals to aerosols of hapten-ovalbumin conjugates. In this way, reactivity toward p-azobenzenearsonate and p-tolyl isocyanate was induced. Carrier (ovalbumin)-specific respiratory reactions were not produced. Hapten-specific respiratory hypersensitivity was accompanied by the production of hapten-specific antibodies. The method for inducing hapten-specific hypersensitivity can be applied to screen various industrial chemicals for their sensitizing abilities toward the respiratory tract.

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