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Comparative Study
. 2011 Mar;22(3):427-35.
doi: 10.1007/s10552-010-9714-3. Epub 2010 Dec 24.

Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study

Lisa A Cadmus Bertram  1 , Marcia L Stefanick, Nazmus Saquib, Loki Natarajan, Ruth E Patterson, Wayne Bardwell, Shirley W Flatt, Vicky A Newman, Cheryl L Rock, Cynthia A Thomson, John P Pierce
Affiliations
Comparative Study

Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study

Lisa A Cadmus Bertram et al. Cancer Causes Control. 2011 Mar.

Abstract

Objective: Research suggests that physical activity is associated with improved breast cancer survival, yet no studies have examined the association between post-diagnosis changes in physical activity and breast cancer outcomes. The aim of this study was to determine whether baseline activity and 1-year change in activity are associated with breast cancer events or mortality.

Methods: A total of 2,361 post-treatment breast cancer survivors (Stage I-III) enrolled in a randomized controlled trial of dietary change completed physical activity measures at baseline and one year. Physical activity variables (total, moderate-vigorous, and adherence to guidelines) were calculated for each time point. Median follow-up was 7.1 years. Outcomes were invasive breast cancer events and all-cause mortality.

Results: Those who were most active at baseline had a 53% lower mortality risk compared to the least active women (HR = 0.47; 95% CI: 0.26, 0.84; p = .01). Adherence to activity guidelines was associated with a 35% lower mortality risk (HR = 0.65, 95% CI: 0.47, 0.91; p < .01). Neither baseline nor 1-year change in activity was associated with additional breast cancer events.

Conclusions: Higher baseline (post-treatment) physical activity was associated with improved survival. However, change in activity over the following year was not associated with outcomes. These data suggest that long-term physical activity levels are important for breast cancer prognosis.

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Figures

Fig. 1
Fig. 1
a All-cause mortality for WHEL Study participants (N = 2,361) stratified by baseline physical activity level. b All-cause mortality stratified by change in physical activity from baseline to 1 year
See this image and copyright information in PMC

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