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. 2011 Apr 15;218(2):346-9.
doi: 10.1016/j.bbr.2010.12.017. Epub 2010 Dec 22.

Alcohol seeking and consumption in the NVHL neurodevelopmental rat model of schizophrenia

S A Berg  1 , C L Czachowski, R Andrew Chambers
Affiliations

Alcohol seeking and consumption in the NVHL neurodevelopmental rat model of schizophrenia

S A Berg et al. Behav Brain Res. .

Abstract

Alcohol abuse in schizophrenia exceeds rates in the general population and worsens illness outcomes. Neonatal ventral hippocampal lesion (NVHL) rats model multiple schizophrenia dimensions including addiction vulnerability. This study compared NVHL vs. SHAM-controls in operant alcohol seeking and consumption. NVHLs enhanced consumption of combined ethanol/sucrose solution but neither ethanol or sucrose only solutions, consistent with increased vulnerability specific to carbohydrate-laden alcohol beverages typically consumed in early stages of human alcoholism.

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Figures

Figure 1
Figure 1
A. Greatest (solid black) and least (white within the black area) extent of damage allowed for rats included in the study. B. Typical example of lesion (top) and SHAM (bottom) histology.
Figure 2
Figure 2
A. Daily intake for the ethanol group of the 10E (left) and 2S/10E (right) solution. B. Daily intake for the sucrose group of the 2S solution.
Figure 3
Figure 3
A. Lever presses during the extinction sessions. B. Percent increase in lever presses for the ethanol group upon switching from the 10E to the 2S/10E solution
See this image and copyright information in PMC

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