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. 2010 May;72(3):397-401.
doi: 10.4103/0250-474X.70494.

Effect of Plant Extracts Formulated in Different Ointment Bases on MDR Strains

Pallavi L Pawar  1 , Bela M Nabar
Affiliations

Effect of Plant Extracts Formulated in Different Ointment Bases on MDR Strains

Pallavi L Pawar et al. Indian J Pharm Sci. 2010 May.

Abstract

Extracts of Aloe vera whole plant, Eucalyptus globulus leaves, Ficus infectoria bark, Ficus religiosa bark and Piper betel leaves were studied for antibacterial activity on resistant and sensitive strains, isolated from skin and soft tissue infections. A combination of hot alcoholic extracts of Ficus infectoria, Ficus religiosa and Piper betel were found to be more effective against all the isolates. The combined extract was formulated in different ointment bases such as polyethylene glycol, gelatin, sodium alginate, carbopol, cream base and honey. These were then evaluated to find a suitable base for preparation of an ointment. In vitro study of the release of antimicrobials and kill-time studies of the herbal ointments was carried out against multi-drug resistant isolate of Pseudomonas. The ointment showed bactericidal activity within 2 h against the resistant strain of Pseudomonas spp.

Keywords: Aloe vera; Eucalyptus globulus; Ficus infectoria; Ficus religiosa; Piper betel; Pseudomonas; multi-drug resistant strains.

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Figures

Fig. 1
Fig. 1
Percentage of different organisms isolated from skin and soft tissue samples. From the skin and soft tissue samples, Staphylococcus spp isolated were 30%, Klebsiella spp isolated were 14%, Enterobacter spp were 12%, Escherichia spp were 7% and Micrococcus spp were 2%.
Fig. 2
Fig. 2
Number of resistant and sensitive strains isolated from the samples. The graph depicts the comparative study of the resistant (■) and sensitive (□) strains isolated from skin and soft tissue samples from patients.
See this image and copyright information in PMC

References

    1. Cohen ML. Changing patterns of infectious disease. Nature. 2000;406:762–7. - PubMed
    1. Shakibaie MR, Mansouri S, Hakak S. Plasmid pattern of antibiotic resistance in beta-lactamase producing Staphylococcus aureus isolated from hospital in Karman. Iran. V J Med Assoc Thailand. 1995;78:403–9.
    1. Gales AC, Jones RN, Pfaller MA, Gordon KA, Sader HS. Two year assessment of pathogen frequency and antimicrobial resistance pattern among organisms isolated from skin and soft tissue infections in Latin American hospitals. Int J Infect Dis. 2000;4:75–84. - PubMed
    1. Visnthikosal V. Effect of Aloe vera gelon heading of burn wounds: A clinical and histological study. J Med Assoc Thailand. 1995;78:403–9. - PubMed
    1. Kapoor LD. CRC Handbook of Ayurvedic Medicinal Plants. Boca Raton (FL): CRC Press. 1990

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