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. 1990 Sep;81(3):441-5.
doi: 10.1111/j.1365-2249.1990.tb05353.x.

The effect of treatment with interferon-gamma on type II collagen-induced arthritis

H Nakajima  1 , H Takamori, Y Hiyama, W Tsukada
Affiliations

The effect of treatment with interferon-gamma on type II collagen-induced arthritis

H Nakajima et al. Clin Exp Immunol. 1990 Sep.

Abstract

We have investigated the effects of recombinant murine interferon-gamma (rIFN-gamma) on type II collagen-induced arthritis (CA) in DBA/l mice. Therapeutic as well as prophylactic treatment with subcutaneous rIFN-gamma, at 10(5) U/mouse six times a week, inhibited the development of CA without any obvious side effects. The accompanying suppression of anti-CII antibody responses may partly explain the inhibition of CA by rIFN-gamma. The possible role of the anti-inflammatory effect of systemic IFN-gamma in the inhibition of CA is discussed.

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References

    1. Biochemistry. 1972 Dec 19;11(26):4903-9 - PubMed
    1. Arthritis Rheum. 1989 Aug;32(8):964-73 - PubMed
    1. Nature. 1980 Feb 14;283(5748):666-8 - PubMed
    1. Prog Hematol. 1981;12:299-339 - PubMed
    1. J Exp Med. 1983 Aug 1;158(2):378-92 - PubMed