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. 2011 Mar;55(3):1274-8.
doi: 10.1128/AAC.01497-10. Epub 2010 Dec 28.

Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007

Mariana Castanheira  1 , Lalitagauri M Deshpande, Dilip Mathai, Jan M Bell, Ronald N Jones, Rodrigo E Mendes
Affiliations

Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007

Mariana Castanheira et al. Antimicrob Agents Chemother. 2011 Mar.

Abstract

Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae strains) isolated in 2006 and 2007 in India, 15 strains carried bla(NDM-1) and 10 harbored a gene encoding a variant of the carbapenemase OXA-48, named bla(OXA-181). One E. cloacae strain harbored bla(VIM-6), and one K. pneumoniae strain carrying bla(OXA-181) also possessed bla(VIM-5). Multiple pulsed-field gel electrophoresis patterns and clonal dissemination within and among sites were observed. Isolates producing NDM-1 were disseminated in Indian health care facilities as early as 2006.

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Figures

FIG. 1.
FIG. 1.
Modified Hodge test (MHT) for NDM-1-producing isolates showing weakly positive results (arrows). Positive and negative controls are included for comparison. MER, meropenem; IMI, imipenem.
See this image and copyright information in PMC

References

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