Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Feb 20;29(6):e150-3.
doi: 10.1200/JCO.2010.32.7825. Epub 2010 Dec 28.

mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome

Heinz-Josef Klümpen, Karla C S Queiroz, C Arnold Spek, Carel J M van Noesel, Helmy C Brink, Wendy W J de Leng, Roeland F de Wilde, Elisabeth M H Mathus-Vliegen, G Johan A Offerhaus, Maarten A Alleman, Anneke M Westermann, Dirk J Richel
Case Reports

mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome

Heinz-Josef Klümpen et al. J Clin Oncol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

AUTHORS’ DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

Although all authors completed the disclosure declaration, the following author(s) indicated a financial or other interest that is relevant to the subject matter under consideration in this article. Certain relationships marked with a “U” are those for which no compensation was received; those relationships marked with a “C” were compensated. For a detailed description of the disclosure categories, or for more information about ASCO’s conflict of interest policy, please refer to the Author Disclosure Declaration and the Disclosures of Potential Conflicts of Interest section in Information for Contributors.

Figures

Fig 1
Fig 1
Follow-up abdominal computed tomography (CT) scan after resection of pancreatic mass. Projections from CT scan with oral and intravenous contrast are shown. (A) A mass in the pancreatic bed with a diameter of 9 cm in January 2009, 6 months after resection (arrows). (B) Repeat CT scan during follow-up 10 months after resection shows a mass of 11 cm in maximal diameter (arrows). (C) Repeat CT scan after 3 months of treatment with everolimus shows a mass of 6 cm (arrows). (D) Repeat CT scan after 6 months of therapy shows a mass of 7 cm (arrows).
Fig 2
Fig 2
(A) DNA sequence analysis of STK11/LKB1 gene. The black arrow marks the location of the mutation in exon 4 (D194E). In the upper sequence, the polyp (P), a heterozygous mutation, is shown; both the wild-type C allele (blue peak) and mutated A allele (green peak) are visible at the arrow. In the lower sequence, which shows the tumor (T), only the mutated A allele (green peak) remains; this is indicative of loss of the wild-type allele. (B) Loss of heterozygosity analysis of marker D19S565 at chromosome 19p, where STK11/LKB1 is located. Note that in the normal tissue (N), both STK11/LKB1 alleles are visible, whereas in the tumor (T), the small allele is missing (left peak, at the arrow), which clearly indicates loss of heterozygosity.
Fig 3
Fig 3
Caspase-3 activity in polyps in response to treatment with everolimus. Polyps collected before and after treatment were immunohistochemically stained for cleaved caspase-3 (active capsase-3) and counterstained with hematoxylin (in blue). The red arrows point to some of the cleaved caspase-3 positive cells (in brown). (A) Polyp tissue collected before treatment. (B) Polyps obtained after 6 months. (C) Polyps obtained after 8 months. Original magnification, ×20
See this image and copyright information in PMC

References

    1. Jenne DE, Reimann H, Nezu J, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. 1998;18:38–43. - PubMed
    1. Hezel AF, Bardeesy N. LKB1: Linking cell structure and tumor suppression. Oncogene. 2008;27:6908–6919. - PubMed
    1. van Lier MG, Wagner A, Mathus-Vliegen EM, et al. High cancer risk in Peutz-Jeghers syndrome: A systematic review and surveillance recommendations. Am J Gastroenterol. 2010;105:1258–1264. - PubMed
    1. Giardiello FM, Brensinger JD, Tersmette AC, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 2000;119:1447–1453. - PubMed
    1. Hardie DG. AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007;8:774–785. - PubMed

MeSH terms

LinkOut - more resources