Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Feb;9(2):131-7.
doi: 10.1038/nrmicro2478. Epub 2010 Dec 29.

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

Marnix H Medema  1 , Rainer Breitling, Roel Bovenberg, Eriko Takano
Affiliations
Review

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

Marnix H Medema et al. Nat Rev Microbiol. 2011 Feb.

Abstract

One of the most promising applications of synthetic biology is the biosynthesis of new drugs from secondary metabolites. Here, we survey a wide range of strategies that control the activity of biosynthetic modules in the cell in space and time, and illustrate how these strategies can be used to design efficient cellular synthetic production systems. Re-engineered versions of secondary metabolite biosynthetic pathways identified from any genomic sequence can then be inserted into these systems in a plug-and-play fashion.

PubMed Disclaimer

References

    1. Nat Prod Rep. 2009 Nov;26(11):1488-503 - PubMed
    1. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7509-14 - PubMed
    1. Nature. 2004 Apr 22;428(6985):868-71 - PubMed
    1. BMC Bioinformatics. 2009 Jun 16;10:185 - PubMed
    1. Nat Prod Rep. 2010 Apr;27(4):571-616 - PubMed

Publication types

MeSH terms

LinkOut - more resources