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. 2011 Jan;52(1):84-6.
doi: 10.1111/j.1472-765x.2010.02971.x.

Chlorine disinfection of Francisella tularensis

H A O'Connell  1 , L J Rose, A M Shams, M J Arduino, E W Rice
Affiliations

Chlorine disinfection of Francisella tularensis

H A O'Connell et al. Lett Appl Microbiol. 2011 Jan.

Abstract

Aims: To determine the range of free available chlorine (FAC) required for disinfection of the live vaccine strain (LVS) and wild-type strains of Francisella tularensis.

Methods and results: Seven strains of planktonic F. tularensis were exposed to 0·5 mg·l(-1) FAC for two pH values, 7 and 8, at 5 and 25°C. LVS was inactivated 2 to 4 times more quickly than any of the wild-type F. tularensis strains at pH 8 and 5°C.

Conclusions: Free available chlorine residual concentrations routinely maintained in drinking water distribution systems would require up to two hours to reduce all F. tularensis strains by 4 log10. LVS was inactivated most quickly of the tested strains.

Significance and impact of the study: This work provides contact time (CT) values that are useful for drinking water risk assessment and also suggests that LVS may not be a good surrogate in disinfection studies.

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