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. 2010 Mar;43(1):1-14.
doi: 10.5115/acb.2010.43.1.1. Epub 2010 Mar 31.

Genomics and proteomics in stem cell research: the road ahead

Sung-Min Ahn  1 , Richard Simpson, Bonghee Lee
Affiliations

Genomics and proteomics in stem cell research: the road ahead

Sung-Min Ahn et al. Anat Cell Biol. 2010 Mar.

Abstract

Stem cell research has been widely studied over the last few years and has attracted increasing attention from researchers in all fields of medicine due to its potential to treat many previously incurable diseases by replacing damaged cells or tissues. As illustrated by hematopoietic stem research, understanding stem cell differentiation at molecular levels is essential for both basic research and for clinical applications of stem cells. Although multiple integrative analyses, such as genomics, epigenomics, transcriptomics and proteomics, are required to understand stem cell biology, proteomics has a unique position in stem cell research. For example, several major breakthroughs in HSC research were due to the identification of proteins such as colony-stimulating factors (CSFs) and cell-surface CD molecules. In 2007, the Human Proteome Organization (HUPO) and the International Society for Stem Cell Research (ISSCR) launched the joint Proteome Biology of Stem Cells Initiative. A systematic proteomics approach to understanding stem cell differentiation will shed new light on stem cell biology and accelerate clinical applications of stem cells.

Keywords: Stem cells; epigenomics; genomics; proteomics; transcriptomics.

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Figures

Fig. 1
Fig. 1
One genome, many epigenomes. Every somatic cell in the human body has almost the same genetic information. Epigenetic changes define accessibility to the genetic information, thus creating cell-type-specific, dynamic genetic templates. In general, stems cells have more open, accessible chromatin structures than differentiated cells.
See this image and copyright information in PMC

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