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. 2010 Dec 10:4:1515-20.
doi: 10.2147/OPTH.S15088.

Pattern-reversal visual-evoked potential in patients with occult macular dystrophy

Gen Hanazono  1 , Hisao Ohde, Kei Shinoda, Kazushige Tsunoda, Kazuo Tsubota, Yozo Miyake
Affiliations

Pattern-reversal visual-evoked potential in patients with occult macular dystrophy

Gen Hanazono et al. Clin Ophthalmol. .

Abstract

Purpose: Occult macular dystrophy (OMD) is a hereditary retinal disease characterized by a normal fundus, normal full-field electroretinograms (ERGs), progressive decrease of visual acuity, and abnormal focal macular ERGs. The purpose of this study was to report pattern-reversal visual-evoked potential (pVEPs) findings in OMD patients.

Patients and method: The pVEPs recorded from four patients with OMD (aged 42-61 years; 2 men and 2 women) were reviewed. The visual acuities ranged from 20/200 to 20/30. The amplitudes of the N-75 and P-100 (P2 amplitude) and the latency of the N-75 components (N1 latency) were analyzed.

Results: The mean (±SD) P2 amplitude was 2.7 ± 1.9 μV for the 5', 4.8 ± 2.9 μV for the 10', 3.2 ± 2.1 μV for the 20', and 4.4 ± 3.5 μV for the 40' checkerboard stimuli. The N1 latency was 122.2 ± 6.4 ms for the 5', 105.0 ± 11.5 ms for the 10', 97.7 ± 10.0 ms for the 20', and 91.0 ± 13.7 ms for the 40' checkerboard stimuli. The mean P2 amplitude was reduced and the N1 latency was delayed in comparison with the laboratory standard for the Keio University Hospital.

Conclusions: The delayed latency and reduced amplitude suggest a major contribution of the central cone pathway to the pVEPs.

Keywords: electroretinogram; occult macular dystrophy; visual-evoked potential.

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Figures

Figure 1
Figure 1
Plot of the A) P2 amplitude and B) N1 latency as a function of the size of the checks of the stimulus for the four patients. The average and the standard error of the means of normal subjects are plotted as the black line. The N1 latency was delayed in all eyes, while the P2 amplitude was reduced in all eyes except both eyes in case 2.
Figure 2
Figure 2
Fundus photograph (above) and fluorescein angiography (below) of case 1 showing no abnormal findings.
Figure 3
Figure 3
A) Goldman perimetry and multifocal electroretinogram (ERG) of case 1. B) Multifocal ERG of cases 2, 3, and 4. Goldman perimetry revealed relative central scotoma of 5° in both eyes. The amplitudes of the multifocal ERGs are reduced in the central area in all cases.
Figure 4
Figure 4
Full-field electroretinogram (ERG) recorded following ISCEV standard protocol. The stimuli are indicated by the arrowheads. Scotopic, bright-flash, photopic, and 30-Hz flicker full-field ERGs are normal.
Figure 5
Figure 5
Focal macular electroretinogram (ERG) (above) and oscillatory potentials (below) recorded from case 1 (left) and normal subject (right). The focal macular ERGs from the patient are clearly smaller than the responses from the normal eye. These ERGs were elicited by 5′, 10′, and 15′ stimulus centered on the fovea. The black bars show the stimulus duration (100 ms). Abbreviations: R, right eye; L, left eye.
Figure 6
Figure 6
pVEPs of case 1 (left) and normal subject (right) elicited by checkerboard stimulus. The N1 latency is delayed and the P2 amplitude is reduced in all the responses elicited by each checkerboard stimuli. The visual angles of the stimuli are shown in the middle. Up arrowheads show N-75 and down arrowheads show P-100. Abbreviations: R, right eye; L, left eye.
See this image and copyright information in PMC

References

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