doi: 10.1016/0014-2999(90)90511-4.
The thyrotropin releasing hormone analogue, RGH 2202, reverses experimental haemorrhagic shock in rats
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- PMID: 2119310
- DOI: 10.1016/0014-2999(90)90511-4
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The thyrotropin releasing hormone analogue, RGH 2202, reverses experimental haemorrhagic shock in rats
Eur J Pharmacol.
.
Abstract
Hypovolemic shock was produced in rats by withdrawing about 50% of the estimated total blood volume. Following mean arterial pressure stabilization in the range of 22-23 mm Hg, the rats were given an i.v. bolus injection of L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline amide (RGH-2202) to be compared with thyrotropin-releasing hormone (TRH). RGH-2202, administered within 5 min following shock induction, dose dependently improved the mean arterial pressure and survival of the rats. The activity of RGH-2202 was superior to that of TRH after i.v. administration; both drugs showed a lower activity after i.m. administration.
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