Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;158(3):505-7.
doi: 10.1016/j.jpeds.2010.11.025. Epub 2010 Dec 28.

Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure

Timothy L McCavit  1 , Charles T Quinn, Chonnamet Techasaensiri, Zora R Rogers
Affiliations

Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure

Timothy L McCavit et al. J Pediatr. 2011 Mar.

Erratum in

  • J Pediatr. 2011 May;158(5):867

Abstract

Invasive pneumococcal disease (IPD) in children with sickle cell disease has decreased with prophylactic penicillin, pneumococcal polysaccharide vaccine, and pneumococcal protein-conjugate vaccine usage. We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Temporal changes in IPD related to PCV7 licensure
A total of 66 cases of IPD were identified before PCV7 licensure (1980–1999) compared with 10 cases from after PCV7 licensure (2000–2009). The frequency of IPD at our center fell to zero shortly after licensure of PCV7 (2001–2003), but there appears to be a recent increase in IPD that started in 2004.
See this image and copyright information in PMC

References

    1. Powars DR. Natural history of sickle cell disease--the first ten years. Semin Hematol. 1975;12:267–85. - PubMed
    1. Barrett-Connor E. Bacterial infection and sickle cell anemia. An analysis of 250 infections in 166 patients and a review of the literature. Medicine (Baltimore) 1971;50:97–112. - PubMed
    1. Pearson HA, Spencer RP, Cornelius EA. Functional asplenia in sickle-cell anemia. N Engl J Med. 1969;281:923–6. - PubMed
    1. Ammann AJ, Addiego J, Wara DW, Lubin B, Smith WB, Mentzer WC. Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. N Engl J Med. 1977;297:897–900. - PubMed
    1. Gaston MH, Verter JI, Woods G, Pegelow C, Kelleher J, Presbury G, et al. Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. N Engl J Med. 1986;314:1593–9. - PubMed

Publication types

Substances