Evaluation of bone mineral density in premature ovarian failure

Abstract

This study was performed to evaluate whether or not early menopause and premature ovarian failure can cause an increased risk of osteoporosis. The bone mineral density (BMD) of the 2nd and 4th lumbar spine as well as femoral neck in 29 cases with secondary amenorrhea were compared with a reference data using a dual-energy X-ray absorptiometry on a bone densitometer: Serum levels of luteinizing hormone, follicular stimulating hormone, calcium and phosphorus were also measured. Both in 20-29 years and in 30-39 years, BMD were significantly lower than their normal range as compared with a reference data from a large study of the same population (P value<0.05). At lumbar vertebrae, 2 cases had osteopenia and 17 had osteoporosis while at the femoral neck, 17 cases had osteopenia and 4 osteoporosis. Only serum levels of phosphorus had positive relationship with femoral neck BMD (P value<0.05). It may be possible to decrease fracture incidence through the early diagnosis of individuals at risk by BMD. In conclusion, our study indicates that females with early onset of menopause and premature ovarian failure had lower value of BMD in both femoral neck and lumbar vertebrae implying the need for more bone health measures.