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Review
. 2011 Oct;118(10):1461-8.
doi: 10.1007/s00702-010-0547-8. Epub 2010 Dec 31.

The pedunculopontine nucleus as a target for deep brain stimulation

Clement Hamani  1 , Elena Moro, Andres M Lozano
Affiliations
Review

The pedunculopontine nucleus as a target for deep brain stimulation

Clement Hamani et al. J Neural Transm (Vienna). 2011 Oct.

Abstract

The pedunculopontine nucleus (PPN) is a brain stem locomotive center that is also involved in the processing of sensory and behavioral information. The PPN has been recently proposed as a potential target for the treatment of axial symptoms in Parkinson's disease (PD). To date, results of the first series of PD patients treated with PPN deep brain stimulation (DBS) have shown promising results. In this article, we review some of the basic aspects of the PPN as a target and the outcome of the recently published clinical trials.

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