FTO and obesity: the missing link
- PMID: 21195343
- DOI: 10.1016/j.cmet.2010.12.016
FTO and obesity: the missing link
Abstract
Genome-wide association studies revealed that variants within FTO (fat-mass- and obesity-associated) are strongly associated with obesity susceptibility. A recent study in Nature Genetics (Church et al., 2010) demonstrates that mice overexpressing fto exhibit a dose-dependent increase in body weight, confirming a role for FTO in the development of obesity.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Overexpression of Fto leads to increased food intake and results in obesity.Nat Genet. 2010 Dec;42(12):1086-92. doi: 10.1038/ng.713. Epub 2010 Nov 14. Nat Genet. 2010. PMID: 21076408 Free PMC article.
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