Comment
doi: 10.1016/j.cmet.2010.12.015.
The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology
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- PMID: 21195344
- DOI: 10.1016/j.cmet.2010.12.015
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Comment
The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology
Cell Metab.
.
Free article
Abstract
How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.Nature. 2010 Dec 2;468(7324):653-8. doi: 10.1038/nature09571. Nature. 2010. PMID: 21124450 Free PMC article.
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Nature. 2010. PMID: 21124451 Free PMC article.
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Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.Nature. 2010 Dec 2;468(7324):701-4. doi: 10.1038/nature09595. Nature. 2010. PMID: 21124456 Free PMC article.
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