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. 2011 Jan-Feb;17(1):64-8.
doi: 10.4103/1319-3767.74470.

Non-invasive predictors of esophageal varices

Jijo V Cherian  1 , Nandan Deepak, Rajesh Prabhu Ponnusamy, Aravindh Somasundaram, V Jayanthi
Affiliations

Non-invasive predictors of esophageal varices

Jijo V Cherian et al. Saudi J Gastroenterol. 2011 Jan-Feb.

Abstract

Background/aim: Current guidelines recommend screening cirrhotic patients with an endoscopy to detect esophageal varices and to institute prophylactic measures in patients with large esophageal varices. In this study, we aimed at identifying non-endoscopic parameters that could predict the presence and grades of esophageal varices.

Patients and methods: In a prospective study, 229 newly diagnosed patients with liver cirrhosis, without a history of variceal bleeding, were included. Demographic, clinical, biochemical and ultrasonographic parameters were recorded. Esophageal varices were classified as small and large, at endoscopy. Univariate analysis and multivariate logistic regression analysis were done to identify independent predictors for the presence and grades of varices.

Results: Of the 229 patients (141 males; median age 42 years; range 17-73 years) with liver cirrhosis, 97 (42.3%) had small and 81 (35.4%) had large varices. On multivariate analysis, low platelet count (Odd's Ratio [OR], 4.3; 95% confidence interval [CI], 1.2-14.9), Child Pugh class B/C (OR, 3.3; 95% CI, 1.8-6.3), spleen diameter (OR, 4.3; 95% CI, 1.6-11.9) and portal vein diameter (OR, 2.4; 95% CI, 1.1-5.3) were independent predictors for the presence of varices. Likewise, for the presence of large esophageal varices, low platelet count (OR, 2.7; 95% CI, 1.4-5.2), Child Pugh class B/C (OR, 3.8; 95% CI, 2.3-6.5) and spleen diameter (OR, 3.1; 95% CI, 1.6-6.0) were the independent risk factors.

Conclusion: The presence and higher grades of varices can be predicted by a low platelet count, Child-Pugh class B/C and spleen diameter. These may be considered as non-endoscopic predictors for the diagnosis and management of large grade varices.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
ROC curve for platelet count in predicting large esophageal varices (AUROC: 0.70)
Figure 2
Figure 2
ROC curve for spleen bipolar diameter in predicting large esophageal varices (AUROC: 0.63)
Figure 3
Figure 3
Algorithm for the initiation of primary prophylaxis for large esophageal varices (LEV) based on the present study
See this image and copyright information in PMC

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