Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Jan-Feb;17(1):69-71.
doi: 10.4103/1319-3767.74455.

Synchronous adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the colon

Padmalaya Devi  1 , Lucy Pattanayak, Sagarika Samantaray
Affiliations
Case Reports

Synchronous adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the colon

Padmalaya Devi et al. Saudi J Gastroenterol. 2011 Jan-Feb.

Abstract

Mucosa-associated lymphoid tissue (MALT) tumors are a distinct subtype of non-Hodgkin's lymphoma. Synchronous appearance of adenocarcinoma and colonic MALT lymphoma in the same patient is quite rare. In the present report, we describe a 68-year-old female who presented with a history of bleeding per rectum. She had no history of fever, loss of weight or drenching night sweats. Rectal examination revealed no abnormality. Colonoscopy showed a large ulceroproliferative mass arising from the hepatic flexure, biopsy of which came out to be adenocarcinoma of colon. A right hemicolectomy was performed and microscopic study revealed the tumor type to be synchronous adenocarcinoma with lymphoma. The final diagnosis of this patient turned out to be a synchronous manifestation of both colonic adenocarcinoma and colonic MALT lymphoma. Although the patient remains asymptomatic two years after surgery, the case highlights the therapeutic dilemma that prevails in the definitive management in such scenarios.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Malignant looking tumor cells arranged in clusters and acinar pattern, containing mucin suggestive of adenocarcinoma
Figure 2
Figure 2
Malignant looking lymphoid cells closely adherent and dispersed along a blood vessel suggesting angiocentricity as seen in high grade lymphomas. Also seen are cells arranged in clusters or acinar pattern suggestive of adenocarcinoma
Figure 3
Figure 3
Infiltration of malignant looking lymphoid cells in the lamina propria suggestive of malt lymphoma
Figure 4
Figure 4
Small to medium sized lymphoid cells having scant to moderate pale eosinophilic cytoplasm. Nucleus is grooved or cleaved with prominent nucleoli, vesicular chromatin. Cells are dispersed along the blood vessel showing angiocentricity and compressing the blood vessel into a slit like appearance
See this image and copyright information in PMC

References

    1. Zucca E, Conconi A, Pedrinis E, Cortezazzo S, Motta T, Mary K, et al. Nongastric marginal zone B-cell lymphoma of mucosa associated lymphoid tissue. Blood. 2003;101:2489–95. - PubMed
    1. Yoshino T, Ichimura K, Mannami T, Takase S, Ohara N, Okada H, et al. Mucosa-associated lymphoid tissue lymphoma often involves the intestine. Cancer. 2001;91:346–53. - PubMed
    1. Gluckman JL, Crissman JD, Donegan JO. Multicentric squamous cell carcinoma of the upper aerodigestive tract. Head Neck Surg. 1980;3:90–6. - PubMed
    1. Zucca E, Roggero E, Bertoni F, Cavalli F. Primary extra-nodal non-Hodgkin’s lymphoma. Part1: Gastro-intestinal, Cutaneous, Genitourinary. Ann Oncol. 1997;8:727–37. - PubMed
    1. Moriya Y, Koyama Y, Minato K, Shimoyama M, Hirota T, Itabashi M. Coexisting malignant lymphoma and advanced adenocarcinoma of the colon: A case report. Gan No Rinsho. 1985;31:894–9. - PubMed

Publication types