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Case Reports
. 2010 Oct;51(10):1157-60.

Granulosa theca cell tumor with erythrocytosis in a llama

David E Anderson  1 , C Guillermo Couto, Michael Oglesbee
Affiliations
Case Reports

Granulosa theca cell tumor with erythrocytosis in a llama

David E Anderson et al. Can Vet J. 2010 Oct.

Abstract
in English, French

A 2.5-year-old, female llama with weight loss and lethargy had a packed cell volume (PCV) of 45% which increased to 57% over 3 wk. Transrectal ultrasonography revealed a mass of mixed echogenicity involving the right ovary, which was removed. A histopathological diagnosis of granulosa theca cell tumor was made. This is the first report of its kind in a llama.

Tumeur de la granulosa et de la thèque avec érythrocytose chez un lama. Un lama femelle âgé de 2,5 ans est présenté avec perte de poids et de la léthargie et une valeur d’hématocrite de 45 % qui a augmenté à 57 % après 3 semaines. Une échographie transrectale a révélé une masse d’échogénicité mixte touchant l’ovaire droit, qui a été retirée. Un diagnostic histopathologique d’une tumeur de la granulosa et de la thèque a été porté. Il s’agit du premier rapport de ce type chez un lama.

(Traduit par Isabelle Vallières)

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Figures

Figure 1
Figure 1
Histologic features of the malignant granulosa cell tumor (A) compared to non-neoplastic cells of an ovarian secondary follicle (B). The secondary follicle contains the oocyte surrounded by a zona pelucida (zp), this being surrounded in turn by the membrana granulosa (mg). The appearance of neoplastic cells was similar to cells from the membrana granulosa, having abundant slightly vacuolated cytoplasm that was well-demarcated. However, the neoplastic cells exhibited moderate atypia and did not form follicular structures, instead assuming a solid pattern of growth. Bars = 50 μm. (C) Vascular invasion by the granulosa cell tumor was widespread, illustrated in this section from the ovarian pedicle, where tumor cells pushed into the lumen of a large vein (arrow). Bar = 100 μm. Formalin-fixed tissue sections (7 μm) were stained with hematoxylin and eosin.
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References

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