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. 2010 Jul 7:3:79-96.
doi: 10.2147/jmdh.s4743.

Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease

Giacomo Levantesi  1 , Maria Giuseppina Silletta, Roberto Marchioli
Affiliations

Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease

Giacomo Levantesi et al. J Multidiscip Healthc. .

Abstract

Much evidence on the favorable effects of omega-3 ethyl esters on cardiovascular morbidity and mortality has been obtained in studies performed in healthy subjects and in different clinical settings. Here the clinical effects of omega-3 ethyl ester administration in patients with previous myocardial infarction or heart failure are reviewed, together with a discussion of underlying mechanisms of action. The pharmacokinetic and pharmacodynamic properties of omega-3 ethyl esters, as well as evidence concerning their safety and tolerability, are also reported.

Keywords: heart failure; myocardial infarction; omega-3 ethyl esters.

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Figures

Figure 1
Figure 1
Randomized controlled trials reporting the effect of n-3 PUFA on cardiac death. Abbreviations: CI, confidence interval; PUFA, polyunsaturated fatty acids.
Figure 2
Figure 2
GISSI-Prevenzione study: Number of lives saved in every 1000 post-MI patients treated with omega-3 EE 1000 mg/day for one year. Abbreviations: CV, cardiovascular; EE, ethyl esters; MI, myocardial infarction.
Figure 3
Figure 3
GISSI-HF study: Number of events avoided every 1000 HF patients treated with omega-3 EE 1000 mg/day for one year. Abbreviations: CV, cardiovascular; EE, ethyl esters; MI, myocardial infarction.
See this image and copyright information in PMC

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