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Clinical Trial
. 2011 May;79(5):431-7.
doi: 10.1111/j.1399-0004.2010.01604.x. Epub 2011 Jan 4.

Breast cancer after bilateral risk-reducing mastectomy

A-B Skytte  1 , D Crüger, M Gerster, A-V Laenkholm, C Lang, K Brøndum-Nielsen, M K Andersen, L Sunde, S Kølvraa, A-M Gerdes
Affiliations
Clinical Trial

Breast cancer after bilateral risk-reducing mastectomy

A-B Skytte et al. Clin Genet. 2011 May.

Abstract

This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

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