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. 2008 Aug 9;64(Pt 9):o1738.
doi: 10.1107/S1600536808025294.

3α-Azido-5-cholestene

Todd A Houston, Sabina Quader, Sue E Boyd, Ian D Jenkins, Peter C Healy

3α-Azido-5-cholestene

Todd A Houston et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro-phobic modification of amino-glycoside anti-biotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions.

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Figures

Fig. 1.
Fig. 1.
The molecular structure of (II), with atom labels and 40% probability displacement ellipsoids for non-H atoms.
Fig. 2.
Fig. 2.
The formation of the title compound.
See this image and copyright information in PMC

References

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