Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Oct;86(4):1369-74.
doi: 10.1172/JCI114849.

In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat

C Cavard  1 , A Zider, M Vernet, M Bennoun, S Saragosti, G Grimber, P Briand
Affiliations

In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat

C Cavard et al. J Clin Invest. 1990 Oct.

Abstract

It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin beta-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

PubMed Disclaimer

References

    1. Methods Enzymol. 1983;101:411-33 - PubMed
    1. Anal Biochem. 1983 Jul 1;132(1):6-13 - PubMed
    1. Science. 1988 Feb 5;239(4840):617-22 - PubMed
    1. Nature. 1988 May 5;333(6168):78-81 - PubMed
    1. Nature. 1988 Oct 13;335(6191):606-11 - PubMed

Publication types

Substances