Human growth factor cream and hyaluronic Acid serum in conjunction with micro laser peel: an efficient regimen for skin rejuvenation

Abstract

The present study investigated the use of a novel hyaluronic acid serum in combination with a cream comprising a mixture of human growth factors in conjunction with the micro laser peel procedure for skin rejuvenation. After preconditioning the face with the hyaluronic acid serum followed by the cream twice daily for one month, 15 female volunteers between 35 to 65 years of age with demonstrable facial wrinkling received a micro laser peel on the entire face using an erbium-doped yttrium aluminium garnet laser. Immediately following the laser procedure, the subjects applied the test products twice daily until the second laser peel one month later. Immediately following the second procedure, the subjects reapplied the test products for another month. In the large majority of subjects, erythema or edema, crusts or erosions, and transitory stinging or burning sensations after the micro laser peel were minimal or mild when the skin was treated with the serum followed by the cream. The micro laser peel in conjunction with the test products helped to significantly improve hyperpigmentation, wrinkles, and texture as compared to before treatment. This study with the micro laser peel device demonstrated that a novel hyaluronic acid serum combined with the human growth factor cream can be successfully used for skin rejuvenation in conjunction with light-to-medium invasive laser skin treatments.

Figure 1

Hyaluronic acid serum 1% followed by human growth factor and cytokine skin cream helped subjects rapidly recover from common adverse events associated with micro laser peel. Erythema, edema, and crusts and erosions are shown as averaged clinical scores of all 15 subjects completing the study. The first micro laser peel was realized on Day 0, the second on Day 30.

Figure 2

Wrinkles, hyperpigmentation, and pores were reduced and skin texture improved after micro laser peels. The improvements in the signs associated with skin aging were particularly pronounced one month after the second peel (Day 60). Reduction is shown as difference in averaged (n=15) clinical score before (baseline) and averaged clinical score after peels expressed in percentage of baseline scores and of all subjects completing the study.

Figure 3

Example of subject demonstrating reduced signs of skin aging after two micro laser peels when using a 1% hyaluronic acid serum in combination with a skin cream containing a mixture of proprietary human growth factors and cytokines as a pre- and postprocedural skin care regimen.

Figure 3

Example of subject demonstrating reduced signs of skin aging after two micro laser peels when using a 1% hyaluronic acid serum in combination with a skin cream containing a mixture of proprietary human growth factors and cytokines as a pre- and postprocedural skin care regimen.