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. 2008 Sep;1(3):16-20.

Efficacy and Tolerability of a Three-Step Acne System Containing a Solubilized Benzoyl Peroxide Lotion versus a Benzoyl Peroxide/Clindamycin Combination Product: An Investigator-Blind, Randomized, Parallel-Group Study

Lawrence J Green, James Q Del Rosso

Efficacy and Tolerability of a Three-Step Acne System Containing a Solubilized Benzoyl Peroxide Lotion versus a Benzoyl Peroxide/Clindamycin Combination Product: An Investigator-Blind, Randomized, Parallel-Group Study

Lawrence J Green et al. J Clin Aesthet Dermatol. 2008 Sep.

Abstract

A brand three-step acne treatment system containing a solubilized 5% benzoyl lotion and a designated cleanser and moisturizer was compared with a brand benzoyl peroxide 5%/clindamycin 1% gel in subjects with acne vulgaris. The single-center, four-week study was investigator-blinded and randomized. The three-step acne treatment system proved to be comparable in efficacy and tolerability.

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Figures

Figure 1
Figure 1
Reduction in non-inflammatory lesion count
Figure 2
Figure 2
Reduction in inflammatory lesion count
Figure 3
Figure 3
Patient rating of effectiveness of treatment
Figure 4
Figure 4
Patient rating of improvement in acne
Figure 5
Figure 5
Mean patient satisfaction score
Figure 6
Figure 6
Mean score for erythema
Figure 7
Figure 7
Mean score for dryness
Figure 8
Figure 8
Mean score for peeling
Figure 9
Figure 9
Mean score for burning/stinging
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References

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    1. Wilson DC. Evaluation of a novel acne treatment system designed to enhance the efficacy of benzoyl peroxide treatment: an investigator-blind, randomized study. Poster #103 presented at: The Summer Academy Meeting 2007 of the American Academy of Dermatology. New York, NY; August 1-5, 2007.
    1. Tanghetti E, Kircik L, Wilson D, Shawan S. Solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in the treatment of moderate acne. J Drugs Dermatol. 2008;7:534–538. - PubMed
    1. Del Rosso JQ. Evaluation of a solubilized benzoyl peroxide gel: a pooled analysis from three randomized investigator-blinded clinical trials. Cosm Dermatol. 2008;21:201–206.
    1. CLENZIderm MD.TM. Introducing a breakthrough acne solution from Obagi. [August 23, 2007]; http://www.obagi.com/article/forpatients/obagiclenzidermmd/clenziderm.html.

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