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. 2011 Feb 14;47(6):1713-5.
doi: 10.1039/c0cc04078a. Epub 2011 Jan 4.

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

Nicholas T Salzameda  1 , Lisa M Eubanks, Joseph S Zakhari, Kyoji Tsuchikama, Nicholas J DeNunzio, Karen N Allen, Mark S Hixon, Kim D Janda
Affiliations

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

Nicholas T Salzameda et al. Chem Commun (Camb). .

Abstract

Clostridium botulinum produces the most lethal toxins known to man, as such they are high risk terrorist threats, and alarmingly there is no approved therapeutic. We report the first cross-over small molecule inhibitor of these neurotoxins and propose a mechanism by which it may impart its inhibitory activity.

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Figures

Fig. 1
Fig. 1
The chemical structure of L-chicoric acid.
Fig. 2
Fig. 2
FRET-based synthetic substrates containing the central region of human VAMP-2.
Fig. 3
Fig. 3
Inhibition of LC/B by L-chicoric acid.
See this image and copyright information in PMC

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References

    1. Gill DM. Microbiol Rev. 1982;46:86. - PMC - PubMed
    1. Simpson LL. Annu Rev Pharmacol Toxicol. 2004;44:167. - PubMed
    1. Willis B, Eubanks LM, Dickerson TJ, Janda KD. Angew Chem Int Ed Engl. 2008;47:8360. - PubMed
    1. Boldt GE, Kennedy JP, Janda KD. Organic Letters. 2006;8:1729. - PMC - PubMed
    1. Capkova K, Hixon MS, McAllister LA, Janda KD. Chem Commun (Camb) 2008:3525. - PubMed

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