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Review

Neuropsychology of Cognitive Aging in Rodents

Joshua S. Rodefer, Mark G. Baxter
David R Riddle  1
, editors.
In: Brain Aging: Models, Methods, and Mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 3.
Frontiers in Neuroscience.
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Review

Neuropsychology of Cognitive Aging in Rodents

Joshua S. Rodefer et al.
Free Books & Documents

Excerpt

Impairments in multiple behavioral domains are observed in aged rodents and a wide variety of neurobiological parameters have been investigated in conjunction with these impairments. These paradigms also provide a setting in which to test possible pharmacological and environmental manipulations that may be able to ameliorate age-related cognitive decline. Careful behavioral design and the use of multiple measures of performance [100] will enhance the ability of experiments in aged rodents to tell us about the biological substrates of cognitive impairment in human brain aging, and will increase the applicability of these models for preclinical development and testing of agents that may be effective cognitive enhancers.

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References

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