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Review

Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey

Jay S. Schneider  1
Edward D Levin  1 , Jerry J Buccafusco  2
, editors.
In: Animal Models of Cognitive Impairment. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 9.
Frontiers in Neuroscience.
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Review

Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey

Jay S. Schneider.
Free Books & Documents

Excerpt

Chronic administration of low doses of the neurotoxin MPTP to macaque monkeys results in primarily attentional and executive function-type cognitive deficits in animals devoid of parkinsonian motor deficits. The fronto-executive deficits in these animals may serve as a model for the cognitive deficits of “early” parkinsonism as well as for the cognitive deficits characteristic of other disorders such as ADHD and chronic schizophrenia. Continued administration of low doses of MPTP to these animals can result in the evolution of a parkinsonian motor disorder, making this a useful animal system for studying the progression of symptoms in parkinsonism.

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References

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